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Foto: Alex Iversen, TV 2. Søsteren Johanne legger heller ikke skjul på at det var godt å se sin kjære igjen etter «Farmen kjendis»-innspillingen, som fant sted i fjor sommer. For Johanne, som tidligere var kjæreste med «Hotel Cæsar»-skuespiller Kim Daniel Sannes, fant nemlig lykken igjen i vinter. Jeg trodde jeg skulle savne både han og hundene veldig, men det gikk bedre enn forventet.

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Microbial N2 fixation diazotrophy represents an important nitrogen source to oligotrophic peatland ecosystems, which are important sinks for atmospheric CO2 and susceptible to changing climate.

The objectives of this study were: i to determine the active microbial group and type of nitrogenase mediating diazotrophy in a ombrotrophic Sphagnum-dominated peat bog the S1 peat bog, Marcell Experimental Forest, Minnesota, USA ; and ii to determine the effect of environmental parameters light, O2, CO2, CH4 on potential rates of diazotrophy measured by acetylene C2H2 reduction and 15N2 incorporation. Molecular analysis of metabolically active microbial communities suggested that diazotrophy in surface peat was primarily mediated by Alphaproteobacteria Bradyrhizobiaceae and Beijerinckiaceae.

Despite higher dissolved vanadium V; 11 nM than molybdenum Mo; 3 nM in surface peat, a combination of metagenomic, amplicon sequencing and activity measurements indicated that Mo-containing nitrogenases dominate over the V-containing form.

Acetylene reduction was only detected in surface peat exposed to light, with the highest rates observed in peat collected from hollows with the highest water content. These results suggest that peatland diazotrophy is mediated by a combination of C2H2-sensitive and C2H2-insensitive microbes that are more active at low O2 and show similar activity at high and low CH4Importance Previous studies indicate that diazotrophy provides an important nitrogen source and is linked to methanotrophy in Sphagnum-dominated peatlands.

However, the environmental controls and enzymatic pathways of peatland diazotrophy, as well as the metabolically active microbial populations that catalyze this process remain in question.

Our findings indicate that oxygen levels and photosynthetic activity override low nutrient availability in limiting diazotrophy, and that members of the Alphaproteobacteria Rhizobiales catalyze this process at the bog surface using the molybdenum-based form of the nitrogenase enzyme. Erionite occurs in volcaniclastic rocks and soils; in some villages in Turkey the presence of erionite in local rocks is associated with mesothelioma, a disease also associated with inhalation of airborne asbestos.

Since volcaniclastic rocks containing erionite are widely present in the western U. Previous attempts to analyze the few micrometer-sized erionite particles found on air sample filters under transmission electron microscope TEM encountered difficulties due to electron beam damage. Recommendations are presented for accurate analysis by both energy-dispersive spectroscopy EDS and selected-area electron diffraction SAED.

Much of the work previously published to establish the crystal chemistry of erionite has involved the relatively large crystals found in vesicles in extrusive volcanic rocks. Analysis of these crystals gives a weight percent ratio of Si to Al in a narrow range around 2. In addition, the cation contents of these crystals generally meet the charge balance error formula for zeolites.

However, erionites formed in volcaniclastic sedimentary rocks tuffs have very different Si:Al weight percent ratios, around 4. Analysis of many particles in samples from different locations reveal two other major differences between the erionites from the sedimentary situations and those found in vesicles. However, sedimentary erionites cannot be termed a separate mineral species because the crystallographic data are consistent with erionite and new zeolite names cannot be proposed on the basis of Si:Al ratios alone.

In addition to chemical differences between erionite from different sources, there are also morphological differences. By analogy with asbestos minerals, differences in composition and morphology may have implications for relative toxicity, and future research should include consideration of these aspects. A licensed, recommended, and age-appropriate vaccine should be used.

For the season, quadrivalent and trivalent influenza vaccines will be available. Live attenuated influenza vaccine LAIV4 is not recommended for use during the season due to concerns about its effectiveness against H1N1 pdm09 viruses during the and seasons.

Recommendations for different vaccine types and specific populations are discussed. No preferential recommendation is made for one influenza vaccine product over another for persons for whom more than one licensed, recommended product is available.

Updates to the recommendations described in this report reflect discussions during public meetings of ACIP held on October 20, ; February 22, ; and June 21, This report focuses on the recommendations for use of vaccines for the prevention and control of influenza during the season in the United States.

These recommendations apply to licensed influenza vaccines used within Food and Drug Administration-licensed indications, including those licensed after the publication date of this report. We assessed generalisability, with respect to socioeconomic status, of estimates from a matched case-control study of valent pneumococcal conjugate vaccine effectiveness for the prevention of invasive pneumococcal disease in children in the USA.

OUTCOME MEASURES: Socioeconomic status was assessed at the individual level via parent interview for enrolled individuals only and birth certificate data for both enrolled and unenrolled individuals and at the neighbourhood level by geocoding to the census tract for both enrolled and unenrolled individuals.

Prediction models were used to determine if socioeconomic status was associated with enrolment. Enrolled cases also tended to come from more affluent census tracts. Despite these differences, our best predictive model for enrolment yielded a concordance statistic of only 0.

Variables retained in the final model were assessed for effect measure modification, and none were found to be significant modifiers of vaccine effectiveness. Our analysis provides evidence that this study design can yield valid estimates and the assessing generalisability of observational data is feasible, even when unenrolled individuals cannot be contacted. In , the Global Commission for the Certification of Polio Eradication certified the eradication of type 2 wild poliovirus, 1 of 3 wild poliovirus serotypes causing paralytic polio since the beginning of recorded history.

Before the switch, immunization programs globally had been using approximately 2 billion tOPV doses per year to immunize hundreds of millions of children. Thus, the globally synchronized withdrawal of tOPV was an unprecedented achievement in immunization and was part of a crucial strategy for containment of polioviruses.

Priority activities included cessation of tOPV production and shipment, national inventories of tOPV, detailed forecasting of tOPV needs, bOPV licensing, scaling up of bOPV production and procurement, developing national operational switch plans, securing funding, establishing oversight and implementation committees and teams, training logisticians and health workers, fostering advocacy and communications, establishing monitoring and validation structures, and implementing waste management strategies.

This article provides an overview of the global efforts and challenges in successfully implementing this unprecedented global initiative, including 1 coordination and tracking of key global planning milestones, 2 guidance facilitating development of country specific plans, 3 challenges for planning and implementing the switch at the global level, and 4 best practices and lessons learned in meeting aggressive switch timelines. Lessons from this monumental public health achievement by countries and partners will likely be drawn upon when bOPV is withdrawn after polio eradication but also could be relevant for other global health initiatives with similarly complex mandates and accelerated timelines.

Vaccination coverage estimates are based provider-reported vaccination histories. Among children who were undervaccinated for MCV and whose parent did not request an exemption, The highest achievable MCV coverage was About 1 in 5 child deaths is a result of unintentional injury.

The leading causes of unintentional injury death vary by age. Prevention strategies for the most common causes are highlighted. Opportunities for lifestyle clinicians to effectively guide their patients and their parents are discussed. This report examines further gains that might be achieved through reduced occurrence of injury-related death.

METHODS: US life tables and injury death rate data were used to estimate potential increases in life expectancy assuming various reductions in the rate of fatal injuries. Corresponding numbers of deaths potentially averted annually were also estimated; unit per death medical and lifetime work loss costs were employed to estimate total costs potentially averted annually. More conservatively, average life expectancy at birth could be increased by 0.

Contemporary evidence-based interventions can play an important role in reducing injury-related deaths, such as those due to drug overdoses and older adult falls, as well as suicides. There has been burgeoning parenting intervention research specifically addressing fathers in recent decades. Corresponding research examining their participation and engagement in evidence-based parent training programs, which have almost exclusively targeted mothers, is just emerging.

The current study used mixed methods to examine factors that influenced completion of an augmented version of an evidence-based child maltreatment prevention program developed for male caregivers called SafeCare Dad to Kids Dad2K in a pilot study.

Logistic regression indicated that, in the context of other demographic predictors, fathers with an education beyond high school were over 5 times more likely to complete Dad2K program compared to fathers with a high school education or less. Qualitative analyses revealed that interviewed father completers were motivated to enroll and participate in a fathering program because of an interest to learn and obtain skills to make them a better parent.

Fathers with a high school education or less may require additional engagement strategies to help proactively encourage their enrollment and completion of parent training programs. This site study was conducted in a chemical laboratory to evaluate nanomaterial emissions from 20? Direct-reading instruments were used to monitor the tasks in real time, and airborne particles were collected using various methods to characterize released nanomaterials using electron microscopy and elemental carbon EC analyses.

CNT clusters and a few high-aspect-ratio particles were identified as being released from some activities. The EC concentration 0. Various sampling methods all indicated different levels of CNTs from the activities; however, the sonication process was found to release the highest amounts of CNTs.

It can be cautiously concluded that the task of probe sonication possibly released nanomaterials into the laboratory and posed a risk of surface contamination. Based on these results, the sonication of CNT suspension should be covered or conducted inside a ventilated enclosure with proper filtration or a glovebox to minimize the potential of exposure.

A collaborative validation study was performed to evaluate the performance of a new U. Food and Drug Administration method developed for detection of the protozoan parasite, Cyclospora cayetanensis, on cilantro and raspberries. The method includes a sample preparation step in which oocysts are recovered from produce using an enhanced produce washing solution containing 0. A real-time PCR assay targeting the C. Five laboratories blindly analyzed a total of samples consisting of 25 g of cilantro or 50 g of raspberries which were either uninoculated or artificially contaminated with C.

Reproducibility between laboratories and analysts was high and the method was shown to be an effective analytical tool for detection of C. Current methods for detecting Flavivirus antibodies are enzyme-linked immunosorbent assays ELISAs and neutralization tests, both of which require laboratories and trained staff.

We evaluated the VectorTest West Nile Virus Antigen Assay in an inhibition platform VecTest-inhibition assay [VIA] as a simpler screening method for detecting antibodies for a variety of flaviviruses among a population of equines from Brazil. The VIA is a potentially useful field test for rapid field-based Flavivirus antibody detection in equine serum samples.

RFFIT has a long history of reproducible and reliable results. The test has been modified over the years to use smaller volumes of reagents and samples, but requires a 50 muL minimum volume of test serum. To conduct pathogenesis studies, small laboratory animals such as mice are regularly tested for rVNA, but the minimum volume for a standard RFFIT may be impossible to obtain, particularly in scenarios of repeated sampling.

To address this problem, a micro-neutralization test was developed previously. In the current study, the micro-neutralization test was compared to the RFFIT using mouse serum samples from rabies vaccine studies. Using a cut-off value of 0. The geometric mean titer of all samples above the cut-off was 2.

These results support continued use of the micro-neutralization test to determine rabies virus neutralizing antibody titers for low-volume serum samples. Although Cr III complexes cannot pass easily through cell membranes, they have the ability to accumulate around cells to induce cell-surface morphological alteration and result in cell-membrane lipid injuries via disruption of cellular functions and integrity, and finally to cause DNA damage.

Cryptosporidium skunk genotype is a zoonotic pathogen commonly identified in surface water. Thus far, no subtyping tool exists for characterizing its transmission in humans and animals and transport in environment. In this study, a subtyping tool based on the 60kDa glycoprotein gp60 gene previously developed for Cryptosporidium chipmunk genotype I was used in the characterization of Cryptosporidium skunk genotype in animal and storm runoff samples from a watershed in New York.

Altogether, 17 positive samples from this watershed and 5 human and animal specimens from other areas were analyzed. We identified 14 subtypes of Cryptosporidium skunk genotype, 11 of which were seen in the watershed. No host-adapted subtypes were identified and the two subtypes in humans were genetically similar to some in raccoons, otters, and storm runoff samples from the watershed.

The characteristics of gp60 protein sequences of the Cryptosporidium skunk genotype are similar to those of other Cryptosporidium species, but only its XVIb subtype family has a putative furin cleavage site.

This subtyping tool might be useful in characterizing Cryptosporidium skunk genotype in clinical and environmental samples. Formaldehyde FA is an environmental chemical classified as a human carcinogen. It is highly reactive and can bind covalently with hemoglobin Hb to produce Hb adducts.

Measurement of these Hb adducts provides valuable information about exposure to this chemical. The peptide is a FA adduct at the N-terminus of the beta chain of human Hb.

The limit of detection was 3. We used these VLPs in biosafety level 2 conditions to efficiently screen MAb cross-neutralization potency. Although binding studies suggest that none of the MAbs compete for the same epitope, combining 11E7, 30F7, or both 11E7 and 30F7 with 8A1 had no additive effect on increasing neutralization in this system. Passaging CCHFV strains in the presence of sub-neutralizing concentrations of MAbs did not generate escape mutants resistant to subsequent neutralization.

Data from the Study to Explore Early Development were used to examine variations in the performance of these instruments by child characteristics and family demographics. For both instruments, specificity decreased as maternal education and family income decreased. Specificity was decreased with lower developmental functioning and higher behavior problems. This suggests that the false positive rates of the SRS and the SCQ are associated with child characteristics and family demographic factors.

There is a need for ASD screeners that perform well across socioeconomic and child characteristics. Clinicians should be mindful of differential performance of these instruments in various groups of children.

This study examines the distribution of travel times to EmONC in Kigoma Region, Tanzania, using various transportation schemes, to estimate the proportion of live births a proxy indicator of women needing delivery care with poor geographic access to EmONC services. A raster-based travel time model was used to map the 2-hour travel time catchment for each mode of transportation.

Live birth density distributions were aggregated by travel time catchments, and by administrative council, to estimate the proportion of births with poor access. As most of the population may only have good EmONC access when using mechanized or motorized vehicles, bicycles and motorcycles should be incorporated into the health transportation strategy. Collaboration between private transportation sectors and obstetric service providers could improve access to EmONC services among most populations.

In areas where residents may not access EmONC facilities within 2 hours regardless of the type of transportation used, upgrading EmONC capacity among nearby non-EmONC facilities may be required to improve accessibility.

Estimating blood demand to determine collection goals challenges many low-income countries. We sampled Tanzanian hospitals to estimate national blood demand. Blood bank registers, patient medical records, and blood component disposition records were reviewed prospectively from June to September to determine the number of components requested and the number and proportion issued, not issued due to nonavailability, and not issued for other reasons.

Data were estimated for an annual national estimate. Of an estimated components requested in , 2. Of these components, 86 In these 3 units, the proportion of units not issued due to nonavailability was 1. Private 4. Of issued components, 91 We evaluated effects of antiretroviral ARV therapy and lipid-based nutrient supplements LNSs on iron, copper, and zinc in milk of exclusively breastfeeding HIV-infected Malawian mothers and their correlations with maternal and infant biomarkers.

ARVs negatively affected copper and zinc milk concentrations, but only at 2 weeks, whereas LNS had no effect.

At 2 weeks, moderately anaemic women produced milk higher in iron when ferritin was higher or TfR lower. At 6 weeks, higher maternal alphaacid glycoprotein and C-reactive protein were associated with higher milk minerals in mildly anaemic women.

Infant TfR was lower when milk mineral concentrations were higher at 6 weeks and when mothers were moderately anaemic during pregnancy. ARV affects copper and zinc milk concentrations in early lactation, and maternal haemoglobin during pregnancy and lactation could influence the association between milk minerals and maternal and infant iron status and biomarkers of inflammation.

Objective: The quantification of inter-segmental spine joint reaction forces during common workplace physical demands. Methods: The current study presents a clinically applicable and noninvasive model which calculates the spinal joint reaction forces at six different regions of the spine.

Subjects completed four ambulatory activities of daily living: level walking, obstacle crossing, stair ascent, and stair descent.

Results: Peak joint spinal reaction forces were compared between tasks and spine regions. Differences existed in the bodyweight normalized vertical joint reaction forces where the walking 8. Conclusion: This method appears to be effective in estimating the joint reaction forces using a segmental spine model.

The results suggesting the main effect of peak reactions forces in the segmental spine can be influenced by task. Purpose A survey of guidelines and current practices was conducted to examine the safe handling procedures for antineoplastic and other hazardous drugs that are used in 24 countries including the Americas, Europe, the Mideast, Far East, and Australia. Methods Subject experts were asked to complete a brief survey regarding safe handling guidelines and practices for hazardous drugs in their countries.

Questions addressed practices for handling monoclonal antibodies, the use of closed-system transfer devices, medical surveillance practices, and measurements of compliance with existing guidelines. Results Responses from 37 subject experts representing 24 countries revealed considerable variation in the content and scope of safe handling guidelines and pharmacy practices among the participating countries.

Others cited international guidelines other than International Society of Oncology Pharmacy Practice, or they have created their own guidelines. Approximately half reported that their guidelines were mandatory under federal, state, or provincial legislation.

Only 11 countries reported that monoclonal antibodies were covered in their guidelines. Closed-system drug-transfer devices are widely used, but were not specifically recommended in four countries, while one country required their use. Medical surveillance programs are in place in 20 countries, but only in The Netherlands is surveillance mandatory. Nine countries reported that they have completed recent updates or revisions of guidelines, and the measures for their adoption have been initiated.

Conclusions Although the overall goals in the participating countries were similar, the approaches taken to assure safe handling of hazardous drugs varied considerably in some cases. The campaign targeted households in 19 out of 91 total health districts. At least one LLIN was present in Access measured as the proportion of the population that could potentially be covered by household-owned LLINs was Campaign process indicators highlighted potential areas for strengthening implementation to optimize access and equity.

Valuable insights may be gained by examining user experiences with a similar licensed technology, a contraceptive ring, especially in settings where this technology may not be currently available. METHODS: In-depth interviews with 24 females enrolled in a trial assessing acceptability and use of a contraceptive ring, and 20 male sexual partners were conducted September April Thematic analysis was completed in MaxQDA FP intentions and disclosure practices were influenced by partner support, socioeconomic factors, religion, cultural beliefs, and societal norms, including female sexuality.

A user-friendly FP design was emphasized. Non-suppression of menstruation was favored by most. Unease with vaginal insertion as well as ring placement issues slippage, expulsion created initial challenges requiring clinician assistance and practice for some participants. During , heroin overdose deaths quadrupled from 3, to 12, 1. Sharp increases in the supply of heroin and illicitly manufactured fentanyl IMF are likely contributing to increased deaths CDC examined trends in unintentional and undetermined deaths involving heroin or synthetic opioids excluding methadone i.

Census regions during Drug exhibits i. All U. Census regions experienced substantial increases in deaths involving heroin from to Since , the South and West experienced increases in heroin drug reports, whereas the Northeast and Midwest experienced steady increases during These broad changes in the U.

International rabies networks have been formed in many of the canine-rabies endemic regions around the world to create unified and directed regional approaches towards elimination. The aim of the first sub-regional Eastern Africa rabies network meeting, which included Kenya, Ethiopia, Tanzania, Rwanda, and Uganda, was to discuss how individual country strategies could be coordinated to address the unique challenges that are faced within the network. The Stepwise Approach towards Rabies Elimination and the Global Dog Rabies Elimination Pathway tool were used to stimulate discussion and planning to achieve the elimination of canine-mediated human rabies by Our analysis estimated a total dog population of Regional approaches to rabies control are of value, as neighboring countries can share their unique challenges while, at the same time, common approaches can be developed and resource-saving strategies can be implemented.

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Science Clips is produced weekly to jegertvillingene snapchat naken awareness of emerging scientific knowledge for the public health community. Each article features an Altmetric Attention score External to track social and mainstream media mentions! Jegertvillingene snapchat naken Ashemale Dis. Open Forum Infect Dis. Acad Forensic Body to body. Revisiting the taxonomy of the genus Elizabethkingia using whole-genome sequencing, optical mapping, and MALDI-TOF, along tegneserier for voksne proposal of three novel Elizabethkingia species: Elizabethkingia bruuniana sp.