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Studies that only included colorectal cancer patients with stage II or III cancer also found this association 10 , 11 , 14 , All studies included in the review are historical cohort studies As a general rule, one cannot draw any conclusions about causality in this type of study.

On the whole, symptoms of malnutrition were measured before toxicity arose, which increases the probability that malnutrition increases the risk of toxic adverse reactions.

The studies primarily used data from patient records to define exposure and outcome variables, which results in high study participation and hence a low risk of selection bias A weakness of using patient record data is that we know little about how systematic the records are.

In the studies that have looked at malnutrition in the form of BMI and weight loss, there is also some lack of clarity with respect to the time of recording weight and height, degree of weight loss, and whether account has been taken of any weight changes during chemotherapy 16 — The number of participants in the different studies varies substantially.

Several have a small number of patients, which reduces the statistical robustness. Five of the studies also include patients with metastatic disease 12 , 13 , 15 , 17 , In these studies, the whole population is analysed together, and we are therefore unable to say anything about the effects for patients with stage II—III cancer in isolation.

However, the studies of Cespedes Feliciano et al. Both conclude that there is a significant association between low muscle mass and dose-reducing toxicity in connection with treatment with a combination of 5-fluorouracil, folinate and oxaliplatin. The results of this study will hopefully yield better answers to whether dose-calculation based on body composition has a part to play in the chemotherapy of the future for this patient population.

In Norway a combination course consisting of 5-fluorouracil, folinate and oxaliplatin has traditionally been administered as a bolus regimen to patients with stage II—III colorectal cancer. In recent years, however, there has been more of a shift to an infusion regimen, as discussed in this review 3. The results of this review show that there is a relationship between clinical signs of disease-related malnutrition and increased chemotherapy toxicity in patients with colorectal cancer.

The results of studies that have investigated low fat-free mass appear particularly convincing. Clinical studies should investigate whether information about body composition should be incorporated in the current dose algorithm or used as guidance for therapy decision at administration.

To ensure that alternative dosage regimens are not at the expense of therapeutic efficacy, it is important that the studies also include survival. The issue is probably also relevant for adjuvant therapy for other types of cancer.

At present, dosage of adjuvant chemotherapy for colorectal cancer patients is based on their surface area, a method that does not take account of individual body composition or pharmacokinetics.

The results of this review indicate that there is a relationship between signs of disease-related malnutrition, particularly low fat-free mass, and the incidence of toxicity and hence modification of the therapy course. Abdominal CT scans are performed routinely for this patient population and can be used to estimate fat-free mass. New technology that enables a faster review of images than previously makes the information more readily accessible to health personnel.

Future clinical studies should investigate the potential for basing chemotherapeutics dosage on body composition in addition to surface area as a step in therapy optimisation. Cancer in Norway — Cancer incidence, mortality, survival and prevalence in Norway. Oslo: Cancer Registry of Norway, Surgical treatment and survival from colorectal cancer in Denmark, England, Norway, and Sweden: a population-based study.

Lancet Oncol ; 74— Nasjonalt handlingsprogram med retningslinjer for diagnostikk, behandling og oppfølging av kreft i tykktarm og endetarm. Oslo: Helsedirektoratet, Norsk Legemiddelhåndbok. Fluorouracil; Oksaliplatin. Common Terminology Criteria for Adverse Events. Medikamentell kreftbehandling — Cytostatikaboken. Oslo: Avdeling for farmakologi, Universitetet i Oslo, A formula to estimate the approximate surface area if height and weight be known.

Simplified calculation of body-surface area. N Engl J Med ; A review of body composition and pharmacokinetics in oncology. Expert Rev Clin Pharmacol ; — Cancer ; — Effect of muscle mass on toxicity and survival in patients with colon cancer undergoing adjuvant chemotherapy. Support Care Cancer ; — Lean body mass as an independent determinant of dose-limiting toxicity and neuropathy in patients with colon cancer treated with FOLFOX regimens.

Cancer Med ; 5: — Effects of gender on capecitabine toxicity in colorectal cancer. J Oncol Pharm Pract ; — Body composition as an independent determinant of 5-fluorouracil-based chemotherapy toxicity. Clin Cancer Res ; —8.

The impact of skeletal muscle on the pharmacokinetics and toxicity of 5-fluorouracil in colorectal cancer. Cancer Chemother Pharmacol ; —7. Ann Surg Treat Res ; — Risk factors for oxaliplatin-induced vascular pain in patients with colorectal cancer and comparison of the efficacy of preventive methods.

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